TREK-1 – perVial.com

Posted on October 3, 2026 by pervial

PE-22-28 vs. Spadin: Comparative Evidence in TREK-1 Potassium Channel Research

3D visualization of a TREK-1 potassium channel embedded in a lipid bilayer with peptide interaction at the pore.

PE-22-28 is a synthetic heptapeptide derived from the natural peptide spadin. Both target the TREK-1 potassium channel, but preclinical evidence shows PE-2

Read more PE-22-28 vs. Spadin: Comparative Evidence in TREK-1 Potassium Channel Research

Posted on August 22, 2026 by pervial

PE-22-28 Research Peptide: Mechanism, TREK-1 Blockade, and Preclinical Evidence

3D molecular visualization of PE-22-28 peptide interacting with the TREK-1 potassium channel.

PE-22-28 is a synthetic, shortened derivative of spadin that selectively inhibits TREK-1 potassium channels, showing rapid-onset neurogenic and antidepress

Read more PE-22-28 Research Peptide: Mechanism, TREK-1 Blockade, and Preclinical Evidence